She has long standing experience in people and resource management, as well as in planning and execution of clinical trials. Kaplan founded Novaremed in Prior to founding Novaremed, Dr. Kaplan practiced medicine in Switzerland. He has more than 30 years of experience in the pharmaceutical industry particularly in oncology drug development. In addition, between and , he founded a consulting firm, Seneb-Pharma, to consult in the field of Research and Development of Drugs and Medical Products.
In he founded AbaNovus, a company providing consultancy and services in the field of methodology and statistics for clinical studies. Hochman joined Novaremed in , as Head of Operations. She has over 22 years of recognized management skills and expertise in the clinical research arena.
At Hesperion Israel, she was being responsible for clinical operations as well as the administration, financial management and human resources. Kobrin is an internist with 15 years of experience in academic medicine both in Israel and the USA. In , Dr. Since , Dr. Kobrin is serving on the Board of Directors of several Swiss biotechnology companies.
Tan currently practices in Singapore, having graduated from medical school in Sidon is an Investment Advisor at Gefen Biomed Investments, an Israeli public company, investing in Israeli startups with disruptive technologies. He has been active in fund raising and portfolio management activities in Israel over the last three decades. He sits of the board of several portfolio companies of Gefen in Israel and abroad.
He has a B. In the past 20 years he held executive positions CSO and CEO and successfully supported or executed mergers, acquisitions, product licensing and turn-around situations. He is an internationally recognized scientists with track record in clinical research of orphan diseases neuromuscular, neuro-ophthalmology.
In , he received the BioValley Basel Award for his outstanding contributions to the life sciences in the area. Zvi Slonimsky is a veteran of the Israeli High Tech industry. Slonimsky holds B. He holds specializations in Internal Medicine, in Diabetology and in Endocrinology.
In addition, Prof. Ziegler is a member of multiple authorized expert panels for clinical guidelines; he has chaired and he is now executive committee member the of Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes EASD editorial boards and Prof. Ziegler has published more than original articles, reviews, and book chapters. His areas of interest are: pathophysiology, pathology, diagnosis, screening, prevention, and treatment of diabetic polyneuropathy, neuropathic pain, cardiovascular autonomic neuropathy, gastrointestinal motility, and erectile dysfunction; design of clinical trials.
He has been principal investigator of numerous clinical trials in diabetic neuropathy for more than 30 years. Attal has published peer review papers on pain particularly neuropathic pain since in high impact factor journals such as Lancet Neurol, Annals Neurol, Neurology, Brain, Pain. Since , she coordinated several European guidelines EFNS, EAN on the assessment, pharmacological and neurostimulation treatment of neuropathic pain.
Since , she is responsible for the panel Pain of the European Academy of Neurology. She is also Chair of the pain panel of the European Academy of Neurology. The system can also be used after a crime is committed to quickly identify criminals from among a general population pool, including suspects. Gefen's risk management leverages its investment funds through the Israeli incubator program under the direction of the Office of the Israel Chief Scientist.
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I was in bed unable to walk for over a week. At least one person claimed to have been sent to the hospital for stitches. Not all accounts of run-ins with Gerald could be verified, but interviews with victims and review of photos and videos of attacks confirmed many. But in late or early , he started to change. Krakauer explained that male turkeys fight each other for dominance and over flocks of hens.
But occasionally, some males misdirect that aggression to include people. The bird is a common sight in Oakland — there are often two or three pecking around the garden. Indeed, Krakauer said, feeding turkeys may make them dangerously accustomed to humans and more likely to approach them. But others doubt this theory, arguing Gerald had been fed for years before his behavior took a turn. She added that had never seen the garden as crowded as it was in the early months of the pandemic.
Many more, including the author Jenny Odell, blame the pandemic too. Odell wrote much of her well-known talk about how we engage with the natural world, How to Do Nothing, while sitting in the Rose Garden. She often observed Gerald, then a perfectly mild-mannered turkey, meandering around.
But with few outdoor oases in walking distance and gyms shutting down, the rose garden got more visitors. Residents of the surrounding neighborhoods came to the garden more frequently. Gerald became increasingly agitated. Odell recalls how Bay Area parks became flooded with visitors after the Covid lockdowns pushed stir-crazy people outdoors. Discussions quickly turned nasty.
Some in the pro-Gerald camp wanted to cede the garden entirely to the bird. Meanwhile, the anti-Gerald camp lobbied to have him euthanized or otherwise removed as soon as possible. This further infuriated the anti-turkey camp, who argued humans should not be locked out of one of our few green spaces in Oakland during the stifling pandemic.
Why are you attacking people? The anti-turkey camp was quick to point out that turkeys are not native to California — having been introduced as hunting targets in the early 20th century — and are seen by some as invasive. It is thought that the brood of rose garden turkeys to which Gerald belonged were forced there in following major fires that pushed them out of the nearby hills.
Valerie Winemiller, who lives a few blocks from the Rose Garden, sees his aggressive behavior as a symbol of human encroachment into natural spaces. It is a wild animal. Gerald was scheduled to be killed on 22 June, to the horror of many on Nextdoor. Concerned neighbors wrote emails to Oakland animal services and the city. A Virginia-based animal rights group called United Poultry Concerns joined the campaign, and an animal sanctuary offered to take Gerald in.
Meanwhile, a war was being waged via flyers posted around the rose garden. Soon after, artistic homages to Gerald reimagined the bird as an Egyptian god. Gerald postersIn response to the intense backlash, the city began looking for alternatives. Representatives from Oakland animal services attempted to re-train Gerald to fear humans — a regimen that involved, among other things, startling him with swiftly opened umbrellas — but to no avail. Eventually, the decision was made to capture and relocate him to a less-populated part of the city.
However, capturing the turkey proved complicated. According to reports in the Oaklandside, staff from animal services and the department of fish and wildlife used ground nets, net guns, robotic turkey calls, and an umbrella painted to resemble a male turkey, all without success.
They even tried to lure Gerald with his favorite foods: blueberries and almonds. Yet by June, more than 20 volunteers had tried and failed to capture him. Dmytryk describes herself as an expert animal trapper, but she still struggled to close in on Gerald. She staked out the park over the course of a month before settling on a new method.
She crouched over as if unable to move, luring in Gerald, before grabbing him by the neck. Little old me? His retirement dreams, however, did not last long. According to the department of fish and wildlife, Gerald found his way into the playground of a new park within a week.
In his absence, one person made an oil painting memorializing him. Ruth Ben-Ghiat delivers a superb examination of how close the US came to fascism — and how it has propped it up beforeThis terrific history of strongmen since Mussolini makes it clear that despite a horrific pandemic and massive economic disruption, ordinary democratic Americans have more to be thankful for this Thanksgiving than ever before.
Almost everything Trump has done has come straight from the authoritarian playbook. Every dictator, for example, has built on the accomplishments of his predecessors. The parallels between Trump and his role models are endless.
The Italian media mogul and prime minister was himself just a pale imitation of Mussolini. In the pre-war period, he was responsible for the deaths of , Libyans, Eritreans, Somalis and Ethiopians. Every authoritarian regime has seen a crucial alliance between big business and the dictator, from Putin and his oligarchs to Hitler and German industrialists and Trump and the Wall Street elite.
The men, women and children he governs have value in his eyes only insofar as they … fight his enemies and adulate him publicly. Kissinger and William F Buckley became fervent Pinochet apologists, even as thousands were tortured and disappeared. In our own time, Trump has never criticized Putin for poisoning his enemies or even putting bounties on US soldiers in Afghanistan.
He has privately boasted about saving the skin of Mohammed bin Salman, after the CIA concluded the Saudi prince had ordered the murder of Jamal Khashoggi, a columnist for the Washington Post. But most of all we owe gigantic thanks to the 80 million decent Americans who voted for Joe Biden and Kamala Harris. It is because of their courage and determination that our badly corroded but still functioning democratic apparatus has proved able to survive.
As Ruth Ben-Ghiat makes all too clear, if we had gone any deeper into this four-year tunnel of doom, none might have escaped it. President-elect is spending the holiday in Delaware with his wife, while vice-president-elect Harris will remain in DC with her husband. Asian shares were mostly higher Thursday, after Wall Street took a pause from the optimism underlined in a record-setting climb earlier in the week. Japan's benchmark Nikkei gained 0.
Can you hear me? It was stolen! Just like all the votes that were stolen by the socialists at Euro Disney! I have a signed affidavit swearing that there was a single dalmatian who voted times! Does this look like a fool?! When I hit capacity, my body excretes Merlot. Read more at The Daily Beast. Get our top stories in your inbox every day. Sign up now! Daily Beast Membership: Beast Inside goes deeper on the stories that matter to you.
Adipose tissue consists mostly of fat stored in adipocytes, but its composition varies considerably with age. Adipose tissues of a newborn baby contain The endomysium intramuscular connective tissues of infants and children is thinner, making their relaxed skeletal muscles significantly softer than those of adults.
Skin tissue is another example of the immense differences between infants and adults in the context of the risk for PUs. First, the thickness of skin tissues in children younger than 5 years of age is lower compared with adults and closer to that of a senior, older than 75 years.
The coefficient of friction of human skin also changes with age, however, since it is relatively low in early life, it does not appear to be an additional biomechanical risk factor for the pediatric population. A competent epidermal barrier in the stratum corneum is necessary at the time of birth for maintaining fluid homeostasis in the extrauterine environment.
Unlike full-term infants, who seem to possess stratum corneum with adult barrier properties, in infants born earlier than 30 weeks of gestational age, there is substantially increased transepidermal water loss. Overall, the decreased stiffness of muscle and fat tissues, together with the reduced extensibility of skin tissues, exposes infants and children to an increased risk for developing PUs.
Since softer tissues will deform more under the same force, pediatric tissues are more susceptible to deformation injuries Fig. Hence, it is of great importance, particularly for the pediatric population, to use a mattress, which will maximize immersion and envelopment and will hence minimize soft tissue deformations during weight-bearing.
They are complex, often involving the whole body, are frequent, present during either wakefulness or sleep, and exhibit pattern changes, as the infant grows older. While recent improvement in both prenatal assistance and neonatal intensive care considerably decreased neonatal mortality, preterm neonates are now more susceptible to CNS dysfunctions related to cerebral insults that occur prenatally or during birth.
While generalized hypotonia suggests prolonged periods in static positions and hence increasing the risk of exceeding tissue tolerance levels, intense jerky movements of the legs, for example, may inflict repetitive compression and shearing forces on the skin and subdermal tissues, subjecting the affected tissues to compressive and shear-force-inflicted damage.
Preterm neonates are often born with decreased muscle tone, as their neuromuscular system is underdeveloped. Usually, extremely premature neonates and especially those born with congenital heart defects have difficulties with breathing, oxygenating, feeding, and thriving.
Since it is customary to postpone heart surgery until the baby is strong enough, these newborns experience prolonged and sedentary hospitalization, which by itself elevates the risk for PU development. This type of ventilation, which is confined to the neonatal and pediatric populations, delivers over breaths per minute, causing high-frequency shear and frictional forces between the support surface and the vibrating infant's body.
Indeed, a higher incidence of skin breakdown in patients ventilated with HFOV than in those ventilated with conventional ventilation has been reported. The altered motility of hospitalized newborns, infants, and children highlights the need for adjustable and adaptable mattresses, which should conform to their body shape and changing positions, as well as minimize shear-deformation-inflicted damage to the skin and subdermal tissues, such as due to repetitive spontaneous movements and HFOV-induced vibrations.
Standard PU risk assessment tools do not account for contact with medical devices and nurse inspections can overlook misplacement of devices and tubing under the body, and so, in theory, if a plastic tube, for example, is caught between the skin and the mattress it is likely to initiate deformation-inflicted soft tissue damage.
Together with poor oxygenation, which is especially common in preterm neonates, sustained contact with tubing or electrodes, even without weight-bearing, will eventually cause necrotic damage to soft tissues. Hence, new bioengineering strategies are needed in this field to target the relevant medical devices, assess risks that they impose, and possibly redesign them so that when they function in isolation or while interacting with other equipment or support surfaces, the risk for device-related PUs will be minimal.
As an illustrative example for such interactions of a device with a support surface and with an infant's body, we developed computer simulations. Specifically, to investigate how a rigid plastic tube deforms the soft tissues of a preterm neonate's arm, when the tube is accidently left between the skin and the mattress, we developed two configurations of a three-dimensional FE computational model of a 3-mm-thick axial cut through the upper arm of a preterm neonate Fig.
We used an idealized cross-sectional geometry of the arm to describe the internal anatomy, including the humerus, muscles, and subcutaneous fat tissues of a 1. The proportions, dimensions, and mechanical properties of the tissues were all adopted from the literature. Next, we fixed the front and back planes of the arm, mattress, and tube in the simulation in the perpendicular direction, to prevent out-of-plane translations so that thin slice modeling conditions were obtained.
We prescribed vertical displacements to the humerus, until a target reaction force of 0. Finally, we compared the local tissue deformations around the tube and the mechanical strains and stresses in the fat and muscle tissues of the simulations. Finite element FE computational model of an axial cut through the upper arm of a 1. Zoom-in on the deformed FE meshes around the tubes is provided in the middle frames. Effective mechanical stress distributions in muscle and fat tissues are on the right.
B, bone; M, muscle; F, fat; T, tube. Overall, the use of an ACB mattress resulted in substantially lower fat and muscle tissue deformations, strains, and stresses around the tube compared to the flat foam mattress, even in the worst-case scenario that was simulated Fig. Furthermore, the ACB mattress's adaptability, namely, its ability to conform buckle around the rigid tube, in this case, allowed for reduced deformations of the subcutaneous fat layer and reduced peaks of effective stresses in the subcutaneous fat and muscle tissues Fig.
Since most of the tubing, wires, and medical devices that are designed to contact the infant's body are overall stiffer than the infant's soft tissues, every sustained contact, especially under weight-bearing conditions, is a tangible threat to tissue health and integrity. Hence, based on the information presented in this article, new specifications should be considered in the design and selection of support surfaces that are to be used in NICUs and PICUs for protecting against PUs.
Such mattresses must be adjustable to the infant's or child's body, as it changes during the period of hospitalization particularly in chronic care , and adaptable, for example, to be able to conform around accidentally misplaced tubes, wires, or electrodes so that tissue deformations in such cases are minimal Fig. Since standard foam hospital mattresses are stiffer than the soft tissues of the body, stiff objects caught between the mattress and the skin will ultimately inflict larger deformation on the tissues rather than on the foam mattress, increasing the risk of PUs and DTIs Fig.
We demonstrated in this study that the ACB-technology is superior in this regard, as it allows extra adaptability, which is not offered by foam technology. PUs in the pediatric population are markedly different from those in adults. Hospitalized newborns are also more susceptible to deformation injuries of their weight-bearing soft tissues and to shear-forces-induced skin damage, due to their soft muscle and fat tissues and skin structure and properties.
Hence, newborns and children deserve unique consideration regarding their PU risk assessment, prevention strategies, support surface design and selection, and treatment protocols. First, such support surfaces should be able to respond to frequent movements and changing positions, while providing the appropriate amount of immersion and envelopment that will keep the weight-bearing soft tissue deformations to a minimum at each posture. Second, especially in chronic care, support surfaces should be able to adjust to longer term changes such as body growth and changes in body mass, tissue structure, and composition, a feature often termed adjustability.
Third, and as emphasized in this article, support surfaces for the pediatric population, particularly in NICUs and PICUs, should be able to effectively adapt and conform around accidentally misplaced tubes, wires, electrodes, or other devices that might contact the skin and deform weight-bearing skin and subdermal soft tissues. The results of our present computer simulations Fig. An ACB mattress protects the infant's tissues in such incidents better than foam mattresses, thanks to the adaptability feature of the ACB support, which in this case manifests as its ability to buckle around the tube, take the deformations off the adjacent tissues, and thereby minimize mechanical strains and stresses in skin, muscle, and fat.
This support is, however, irrelevant to the data that were presented and the conclusions that were made here. No competing financial interests exist. The content of this article was expressly written by the authors listed. No ghostwriters were used to write this article.
Her doctoral work focuses on novel strategies and technologies for preventing pressure ulcers. His research interests are in studying normal and pathological effects of biomechanical factors on the structure and function of cells, tissues, and organs, with emphasis on applications in chronic wound research. Gefen has published more than articles in peer-reviewed international journals, many of which are on chronic wounds and their prevention, and he has edited several relevant books.
In , he was elected as a fellow of the International Academy of Medical and Biological Engineering. National Center for Biotechnology Information , U. Advances in Wound Care. Adv Wound Care New Rochelle. Find articles by Ayelet Levy. Find articles by Kara Kopplin. Find articles by Amit Gefen. Author information Article notes Copyright and License information Disclaimer.
Received Jan 28; Accepted Mar Copyright , Mary Ann Liebert, Inc. This article has been cited by other articles in PMC. Abstract Significance: Pressure ulcers PUs in newborns and children are remarkably different from those in adults, both in their possible causal factors and in the etiology and biomechanical pathways for tissue damage. Open in a separate window. Amit Gefen, PhD. Scope and Significance Pressure ulcers PUs are highly prevalent in neonatal and pediatric intensive care units NICUs and PICUs, respectively and are different from those of adults in their causal factors, etiology, and characteristics.
Translational Relevance In this article, we employed a finite element FE computational modeling method to investigate biomechanical interactions between the soft weight-bearing tissues of a preterm neonate's arm and a plastic tube, which is caught between the skin and the mattress. Clinical Relevance In the field of PU prevention, it is perilous to consider children simply as scaled-down adults.
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Major Products and Services 2. Markets and Sales Activities 2. Locations, Subsidiaries, Operating Units. Financial Statements 4. Income Statement 4. Balance Sheet 4. Cash Flow 4. Financial Ratios 4. Profitability 4. Margin Analysis 4. Asset Turnover 4. Credit Ratios 4. Long-Term Solvency 4. Growth Over Prior Year 4. Financial Ratios Charts 4. Stock Market Snapshot. IR Corporate News 6. Marketing News 6. Corporate Events. Political Factors 9.
Economic Factors 9. Social Factors 9. Technological Factors 9. Environmental Factors 9. Legal Factors. Internal Factor Evaluation Matrix External Factor Evaluation Matrix Internal External Matrix. The complete financial data is available for publicly traded companies. Industry Income Statement Analysis Company vs. Industry Balance Sheet Analysis Company vs. Industry Cash Flow Analysis Company vs. SWOT, which stands for Strengths, Weaknesses, Opportunities and Threats, is an analytical framework that identifies the internal and external factors that are favorable and unfavorable for a company.
Upon answering these questions a company can develop a project plan to improve its business performance. PESTEL also termed as PESTLE is an ideal tool to strategically analyze what influence different outside factors — political, economic, sociocultural, technological, environmental and legal — exert on a business to later chart its long term targets.
Being part of the external analysis when carrying out a strategic assessment or performing a market study, PESTEL gives an overview of diverse macro-environmental factors that any company should thoughtfully consider.
By perceiving these outside environments, businesses can maximally benefit from the opportunities while minimizing the threats to the organization. In addition, IFE matrix serves as a basis for identifying and assessing relationships amongst those areas. The IFE matrix is utilised in strategy formulation. The External Factor Evaluation matrix EFE matrix is a tool of strategic management that is typically utilised to assess current market conditions. It is an ideal instrument for visualising and prioritising the threats and opportunities a firm is facing.
The essential difference between the above mentioned matrices lies in the type of factors incorporated in the model; whilst the latter is engaged in internal factors, the former deals exceptionally with external factors — those exposed to social, political, economic, legal, etc. Being a continuation of the EFE matrix and IFE matrix models, the Internal External matrix IE matrix rests upon an investigation of external and internal business factors integrated into one suggestive model.
The analysis surveys an industry through five major questions:. Advanced search. Wire Transfer. Checkout Later. Need Help? Ask a Question. All available data is presented in a comprehensive and easily accessed format. The report includes financial and SWOT information, industry analysis, opinions, estimates, plus annual and quarterly forecasts made by stock market experts. The report also enables direct comparison to be made between Gefen Biomed Investments Ltd and its competitors. The report contains detailed information about Gefen Biomed Investments Ltd that gives an unrivalled in-depth knowledge about internal business-environment of the company: data about the owners, senior executives, locations, subsidiaries, markets, products, and company history.
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Grant Providers. Corporate Accelerators. Co-working Spaces. Entrepreneurship Programs. About us. Log in. Gefen Biomed Investments. Read More. Read Less. Green technologies: innovation in producing or using commodities like water and energy sources in a sustainable manner. Qualification as "green" or "sustainable" is subjective but typically represents a method of minimizing the extraction of Earth's natural resources and disruption to ecosystems.
Medical devices are instruments or accessories intended for use in the diagnosis of diseases and other conditions. Innovation in microscopic levels of organisms or control of microscopic life, usually dealing with genes, molecular materials, or biopesticides.
The use of technology to reshape the delivery and consumption of healthcare. Digital Health is making medicine more personal, continuous, accurate, and data-driven.
First name You must enter entered is incorrect. How big is the bargaining. Tell us about your business. Work email The email you. Check your inbox or spam. Locations, Subsidiaries, Operating Units 3. Last name You must enter. Legal Factors Internal External Matrix least one digit8 composes a threat of substitute and one lowercase letter a-z. Environmental - What environmental and all necessary data in our database to prepare the report of the threats. What is the intensity of new competitors entering the market.Gefen Biomed Investments was a venture capital firm that used to invest in early-stage medical and biotechnology companies. The firm was based in Ashkelon. Gefen Biomed Investments engages in the location, screening, and investment in early-stage biotechnology and medical technology companies. Investors; Longevity Industry in Israel Landscape. 1. Group Gefen Biomed Investments. The Children's Hospital of Philadelphia