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Gastroenterology Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization. World J Gastroenterol — Important review summarizing the HBV replication. The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes.

J Virol. Hepatitis B virus genome is organized into nucleosomes in the nucleus of the infected cell. Virus Genes. Structural organization of the hepatitis B virus minichromosome. J Mol Biol. Control of cccDNA function in hepatitis B virus infection.

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Front Cell Infect Microbiol. Towards HBV curative therapies. J Cell Biochem. J Biol Eng. Nature — Study demonstrating that SaCas9 can mediate genome editing in vivo with high specificity. Sci Rep Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation.

Antimicrob Agents Chemother. Host-targeting agents for treatment of hepatitis B virus infection. Curr Opin Virol. Int J Mol Sci. PLoS Pathog. Biochem Biophys Res Commun. Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus. Nat Microbiol. In press. A important study identify the minimal set of factors for cccDNA formation. Ji X, Li Z. Medicinal chemistry strategies toward host targeting antiviral agents. Med Res Rev In press doi. Dandri M. Epigenetic modulation in chronic hepatitis B virus infection.

Semin Immunopathol. Deeks SG. HIV: Shock and kill. Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents. Quasdorff M, Protzer U. Control of hepatitis B virus at the level of transcription. J Viral Hepat. Hepatocyte metabolic signalling pathways and regulation of hepatitis B virus expression.

Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection. J Clin invest — Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes. PLoS One. Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.

Function and information content of DNA methylation. Transcription of hepatitis B virus covalently closed circular DNA is regulated by CpG methylation during chronic infection. Gastroenterology — Identification of the enzymatic activities that modulate the acetylation of cccDNA-bound histones as new therapeutic targets for HBV cure. Int J Med Sci. SAT antiviral activityof GS, a liver-targeted prodrug of a lysine demethylase 5 inhibitor, in a hepatitis B virus primary human hepatocyte infection model.

Virus-host interplay in hepatitis B virus infection and epigenetic treatment strategies. FEBS J. Core protein: a pleiotropic keystone in the HBV lifecycle. Can we cure hepatitis B virus with novel direct-acting antivirals? HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways. Science — Discovery of novel hepatitis B virus nucleocapsid assembly inhibitors.

ACS Infect Dis. Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly. Inhibition of human hepatitis B virus HBV by a novel non-nucleosidic compound in a transgenic mouse model. Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication. Bioorg Med Chem Lett. Phenylpropenamide derivatives AT and AT inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro.

J Virol — Discovery of new hepatitis B virus capsid assembly modulators by an optimal high-throughput cell-based assay. Discovery of a new sulfonamide hepatitis B capsid assembly modulator. Amblard F, Boucle S, Bassit L, et al Novel hepatitis B virus capsid assembly modulator induces potent antiviral responses in vitro and in humanized mice. JNJ, an HBV capsid assembly modulator, is well-tolerated and has antiviral activity in a phase 1 study of patients with chronic infection.

Gastroenterology In press doi. Targets and future direct-acting antiviral approaches to achieve hepatitis B virus cure. Safety, pharmacokinetics, and antiviral effects of ABI-H, a hepatitis B virus core inhibitor: a randomised, placebo-controlled phase 1 trial. New targets and possible new therapeutic approaches in the chemotherapy of chronic hepatitis B. Pathogenesis of hepatitis B virus infection.

Pathol Biol Paris. Boni C, Vecchi A, Rossi M, et al TLR7 agonist increases responses of hepatitis B virus-specific T cells and natural killer cells in patients with chronic hepatitis B treated with nucleos t ide analogues. Upcoming pharmacological developments in chronic hepatitis B: can we glimpse a cure on the horizon?

BMC Gastroenterol. Lanford RE, Guerra B, Chavez D, et al GS, an oral agonist of toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology —, Sustained efficacy and seroconversion with the toll-like receptor 7 agonist GS in the woodchuck model of chronic hepatitis B. J Viral Hepat — Clin Liver Dis — Sustained efficacy and surface antigen seroconversion in the woodchuck model of chronic hepatitis B with the selective toll-like receptor 8 agonist GS Regulation of toll-like receptor-2 expression in chronic hepatitis B by the precore protein.

Expression profiles and function of toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients. Clin Immunol Orlando Fla. Antivir Ther — This study suggested clinical differences observed across the CHB spectrum. Hepatitis B virus evasion from cyclic guanosine monophosphate—adenosine monophosphate synthase sensing in human hepatocytes. Antiviral efficacy and host innate immunity associated with SB treatment in the woodchuck model of chronic hepatitis B.

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Research progress of therapeutic vaccines for treating chronic hepatitis B. Hum Vaccines Immunother. The design and development of a multi-HBV antigen encoded in chimpanzee adenoviral and modified vaccinia Ankara viral vectors; a novel therapeutic vaccine strategy against HBV.

Programmed cell death ligand a dynamic immune checkpoint in cancer therapy. Chem Biol Drug Des In press doi. Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection. Elimination of hepatitis B: is it a mission possible?

BMC Med. Medicine Baltimore. Fulminant myocarditis with combination immune checkpoint blockade. N Engl J Med. Lake AC. Hepatitis B reactivation in a long-term nonprogressor due to nivolumab therapy. For reasons of protection, we ask you to provide evidence that you are a human being, before continuing in using our service.

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